Issue 88, 2016

Spatial organization based reciprocal switching of enzyme-free nucleic acid circuits

Abstract

We report a new nucleic acid sensing strategy through an intelligent design of spatial organization based reciprocal switching of catalytic hairpin assembly (CHA). The so-called SORS-CHA not only turns a well-designed CHA circuit into a relatively universal detector for any targeting sequence, but also guarantees a much enhanced signal resolution and a believability to minimize the misreading induced by unexpected signal drifts. With more trustworthy results, but a simpler sequence design, nucleic acid circuits could become competitive in real-world applications.

Graphical abstract: Spatial organization based reciprocal switching of enzyme-free nucleic acid circuits

Supplementary files

Article information

Article type
Communication
Submitted
01 Sep 2016
Accepted
10 Oct 2016
First published
10 Oct 2016

Chem. Commun., 2016,52, 13043-13046

Spatial organization based reciprocal switching of enzyme-free nucleic acid circuits

Y. Tang, Z. Zhu, B. Lu and B. Li, Chem. Commun., 2016, 52, 13043 DOI: 10.1039/C6CC07153H

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