Issue 83, 2016
From the journal:

Chemical Communications

Spatially well-defined carbohydrate nanoplatforms: synthesis, characterization and lectin interaction study†

B. J. J. Timmer,‡a   M. Abellán Flos,‡b   L. Mønster Jørgensen,c   D. Proverbio,c   S. Altun,c   O. Ramström,*a   T. Aastrup*c  and  S. P. Vincent*b  

* Corresponding authors

a KTH – Royal Institute of Technology, Department of Chemistry, Organic Chemistry, Teknikringen 36, S-100 44 Stockholm, Sweden
E-mail: ramstrom@kth.se

b University of Namur, Départment de Chimie, Laboratoire de Chimie Bio-Organique, Rue de Bruxelles 61, B-5000 Namur, Belgium
E-mail: stephane.vincent@unamur.be

c Attana AB, Björnnäsvägen 21, SE-114 19 Stockholm, Sweden
E-mail: teodor.aastrup@attana.com

Abstract

Two novel dodecasubstituted carbohydrate nanoplatforms based on molecular Borromean rings and dodecaamine cages have been prepared for use in evaluating the importance of the spatial distribution of carbohydrates in their interaction with lectins. The binding affinities of the glyconanoplatforms were characterized using quartz crystal microbalance technology and compared with a monovalent reference and dodecaglycosylated fullerenes.

Graphical abstract: Spatially well-defined carbohydrate nanoplatforms: synthesis, characterization and lectin interaction study

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Article information

DOI
https://doi.org/10.1039/C6CC06737A
Article type
Communication
Submitted
16 Aug 2016
Accepted
20 Sep 2016
First published
20 Sep 2016
This article is Open Access
Creative Commons BY-NC license

Chem. Commun., 2016,52, 12326-12329

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Spatially well-defined carbohydrate nanoplatforms: synthesis, characterization and lectin interaction study

B. J. J. Timmer, M. A. Flos, L. M. Jørgensen, D. Proverbio, S. Altun, O. Ramström, T. Aastrup and S. P. Vincent, Chem. Commun., 2016, 52, 12326 DOI: 10.1039/C6CC06737A

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