Issue 94, 2016

Palladium-catalyzed dearomative arylalkynylation of indoles

Abstract

A palladium-catalyzed indole dearomative bisfunctionalization via a domino arylation/alkynylation sequence has been developed, which provides a reliable approach to a series of structurally diverse tetracyclic indolines bearing vicinal tertiary and quaternary stereocenters in moderate to good yields and excellent diastereoselectivities.

Graphical abstract: Palladium-catalyzed dearomative arylalkynylation of indoles

Supplementary files

Article information

Article type
Communication
Submitted
28 Jul 2016
Accepted
29 Sep 2016
First published
29 Sep 2016

Chem. Commun., 2016,52, 13664-13667

Palladium-catalyzed dearomative arylalkynylation of indoles

R. Liu, T. Xu, Y. Wang, B. Xiang, J. Gao and Y. Jia, Chem. Commun., 2016, 52, 13664 DOI: 10.1039/C6CC06262H

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