Issue 81, 2016

Tandem neopentyl glycol maltosides (TNMs) for membrane protein stabilisation

Abstract

A novel class of detergents, designated tandem neopentyl glycol maltosides (TNMs), were evaluated with four target membrane proteins. The best detergent varied depending on the target, but TNM-C12L and TNM-C11S were notable for their ability to confer increased membrane protein stability compared to DDM. These agents have potential for use in membrane protein research.

Graphical abstract: Tandem neopentyl glycol maltosides (TNMs) for membrane protein stabilisation

Supplementary files

Article information

Article type
Communication
Submitted
26 Jul 2016
Accepted
13 Sep 2016
First published
13 Sep 2016

Chem. Commun., 2016,52, 12104-12107

Tandem neopentyl glycol maltosides (TNMs) for membrane protein stabilisation

H. E. Bae, J. S. Mortensen, O. Ribeiro, Y. Du, M. Ehsan, B. K. Kobilka, C. J. Loland, B. Byrne and P. S. Chae, Chem. Commun., 2016, 52, 12104 DOI: 10.1039/C6CC06147H

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