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Issue 81, 2016
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Stabilisation of metastable polymorphs: the case of paracetamol form III

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Abstract

The design of a melt synthesis of the first air-stable formulation of the metastable form III of paracetamol is derived from thermo-spectroscopic and thermo-diffraction experiments. Melt crystallisation in the presence of β-1,4-saccharides produces form III selectively and the excipients appear to act as stabilising ‘active’ templates of the metastable polymorph.

Graphical abstract: Stabilisation of metastable polymorphs: the case of paracetamol form III

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Publication details

The article was received on 15 Jun 2016, accepted on 05 Aug 2016 and first published on 05 Aug 2016


Article type: Communication
DOI: 10.1039/C6CC05006A
Citation: Chem. Commun., 2016,52, 12028-12031
  • Open access: Creative Commons BY-NC license
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    Stabilisation of metastable polymorphs: the case of paracetamol form III

    R. Telford, C. C. Seaton, A. Clout, A. Buanz, S. Gaisford, G. R. Williams, T. J. Prior, C. H. Okoye, T. Munshi and I. J. Scowen, Chem. Commun., 2016, 52, 12028
    DOI: 10.1039/C6CC05006A

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