Issue 70, 2016
From the journal:

Chemical Communications

Binding-responsive catalysis of Taq DNA polymerase for the sensitive and selective detection of cell-surface proteins†

Zhuxin Wang,a   Yifei Li,ab   Peng Han,a   Xiaoxia Mao,a   Yongmei Yin*c  and  Ya Cao*a  

* Corresponding authors

a Center for Molecular Recognition and Biosensing, School of Life Sciences, Shanghai University, Shanghai 200444, China
E-mail: conezimint@shu.edu.cn

b Shanghai Key Laboratory of Bio-Energy Crops, Shanghai University, Shanghai 200444, China

c Department of Oncology, The First Affiliated Hospital of Nanjing Medical University, Nanjing 210029, China
E-mail: ym.yin@hotmail.com

Abstract

Here we develop a new method for the sensitive and selective detection of cell-surface proteins with an aptamer probe designed for binding-responsive catalysis of Taq DNA polymerase. Taking the biotin receptor as a model, the method allows the detection of target protein on surfaces of different types of cancer cells.

Graphical abstract: Binding-responsive catalysis of Taq DNA polymerase for the sensitive and selective detection of cell-surface proteins

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Article information

DOI
https://doi.org/10.1039/C6CC04351H
Article type
Communication
Submitted
24 May 2016
Accepted
02 Aug 2016
First published
02 Aug 2016

Chem. Commun., 2016,52, 10684-10687

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Binding-responsive catalysis of Taq DNA polymerase for the sensitive and selective detection of cell-surface proteins

Z. Wang, Y. Li, P. Han, X. Mao, Y. Yin and Y. Cao, Chem. Commun., 2016, 52, 10684 DOI: 10.1039/C6CC04351H

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