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Issue 53, 2016
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Synthesis of models of the BC ring systems of MPC1001 and MPC1001F

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Abstract

Piperazinedione 13, representing the BC rings of the anti-prostate cancer fungal metabolite MPC1001, was prepared by a route in which a sulfur-stabilized carbanion derived from 22 cyclizes onto the terminal ester of the pendant chain attached to N1. Another model, 14, was synthesized by cyclization of an α-ketoamide nitrogen onto an ester; 14 represents the BC rings of MPC1001F.

Graphical abstract: Synthesis of models of the BC ring systems of MPC1001 and MPC1001F

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Publication details

The article was received on 18 May 2016, accepted on 07 Jun 2016 and first published on 07 Jun 2016


Article type: Communication
DOI: 10.1039/C6CC04169H
Author version available: Download Author version (PDF)
Citation: Chem. Commun., 2016,52, 8271-8274
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    Synthesis of models of the BC ring systems of MPC1001 and MPC1001F

    S. Dong, K. Indukuri, D. L. J. Clive and J. Gao, Chem. Commun., 2016, 52, 8271
    DOI: 10.1039/C6CC04169H

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