Issue 44, 2016
From the journal:

Chemical Communications

Rod-shaped and fluorine-substituted hydroxyapatite free of molecular immunopotentiators stimulates anti-cancer immunity in vivo†

Xiupeng Wang,*a   Xia Li,a   Atsuo Ito,a   Yohei Watanabeb  and  Noriko M. Tsujib  

* Corresponding authors

a Health Research Institute, Department of Life Science and Biotechnology, National Institute of Advanced Industrial Science and Technology (AIST), Central 6, 1-1-1 Higashi, Tsukuba, Ibaraki 305-8566, Japan
E-mail: xp-wang@aist.go.jp

b Immune Homeostasis Lab., Biomedical Research Institute, Department of Life Science and Biotechnology, National Institute of Advanced Industrial Science and Technology (AIST), Central 6, 1-1-1 Higashi, Tsukuba, Ibaraki 305-8566, Japan

Abstract

Herein, rod-shaped and fluorine-substituted hydroxyapatite nanoparticles (FHA) were synthesized using a facile hydrothermal method. The rod-shaped FHA significantly increased the cellular uptake of a model antigen by bone marrow dentritic cells in vitro, improved antigen presentation in vivo, stimulated immune-related cytokine secretion in vitro and ex vivo, and enhanced the anti-cancer immunity in vivo.

Graphical abstract: Rod-shaped and fluorine-substituted hydroxyapatite free of molecular immunopotentiators stimulates anti-cancer immunity in vivo

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Article information

DOI
https://doi.org/10.1039/C6CC02848A
Article type
Communication
Submitted
06 Apr 2016
Accepted
19 Apr 2016
First published
21 Apr 2016
This article is Open Access
Creative Commons BY-NC license

Chem. Commun., 2016,52, 7078-7081

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Rod-shaped and fluorine-substituted hydroxyapatite free of molecular immunopotentiators stimulates anti-cancer immunity in vivo

X. Wang, X. Li, A. Ito, Y. Watanabe and N. M. Tsuji, Chem. Commun., 2016, 52, 7078 DOI: 10.1039/C6CC02848A

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