Issue 56, 2016

A molecular beacon-based DNA switch for reversible pH sensing in vesicles and live cells

Abstract

In this Communication, a molecular beacon-based DNA switch (LMB) is developed as an efficient and reversible pH sensing probe. Remarkably, LMB exhibited reversible structural transition between the closed (molecular beacon) and open (A-motif) states very efficiently in synthetic vesicles and live cells without the need for any transfection agents.

Graphical abstract: A molecular beacon-based DNA switch for reversible pH sensing in vesicles and live cells

Supplementary files

Article information

Article type
Communication
Submitted
31 Mar 2016
Accepted
15 Jun 2016
First published
15 Jun 2016

Chem. Commun., 2016,52, 8741-8744

A molecular beacon-based DNA switch for reversible pH sensing in vesicles and live cells

N. Narayanaswamy, R. R. Nair, Y. V. Suseela, D. K. Saini and T. Govindaraju, Chem. Commun., 2016, 52, 8741 DOI: 10.1039/C6CC02705A

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