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Issue 47, 2016
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A reversible B–A transition of DNA duplexes induced by synthetic cationic copolymers

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Abstract

Although the B-form duplex is the canonical DNA structure, the A-form duplex plays critical roles in controlling gene expression. Here, reversible B–A transitions of DNA duplexes were induced by synthetic cationic and anionic polymers. Thermodynamic analysis demonstrated that the B–A transition was regulated by the dehydration of the DNA duplex caused by polymer binding.

Graphical abstract: A reversible B–A transition of DNA duplexes induced by synthetic cationic copolymers

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Publication details

The article was received on 14 Mar 2016, accepted on 13 May 2016 and first published on 16 May 2016


Article type: Communication
DOI: 10.1039/C6CC02237E
Citation: Chem. Commun., 2016,52, 7446-7449
  • Open access: Creative Commons BY license
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    A reversible B–A transition of DNA duplexes induced by synthetic cationic copolymers

    N. Yamaguchi, Y. Zouzumi, N. Shimada, S. Nakano, N. Sugimoto, A. Maruyama and D. Miyoshi, Chem. Commun., 2016, 52, 7446
    DOI: 10.1039/C6CC02237E

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