Issue 47, 2016
From the journal:

Chemical Communications

A reversible B–A transition of DNA duplexes induced by synthetic cationic copolymers†

Nonoka Yamaguchi,a   Yu-ki Zouzumi,a   Naohiko Shimada,b   Shu-ichi Nakano,a   Naoki Sugimoto,ac   Atsushi Maruyama*b  and  Daisuke Miyoshi*a  

* Corresponding authors

a Faculty of Frontiers of Innovative Research in Science and Technology (FIRST), Konan University, 7-1-20 Minatojima-minamimachi, Chuo-ku, Kobe 650-0047, Japan

b Department of Biomolecular Engineering, Graduate School of Bioscience and Biotechnology, Tokyo Institute of Technology, 4259 Nagatsuta, Midori-ku, Yokohama 226-8501, Japan

c Frontier Institute for Biomolecular Engineering Research (FIBER), Konan University, 7-1-20 Minatojima-minamimachi, Chuo-ku, Kobe 650-0047, Japan

Abstract

Although the B-form duplex is the canonical DNA structure, the A-form duplex plays critical roles in controlling gene expression. Here, reversible B–A transitions of DNA duplexes were induced by synthetic cationic and anionic polymers. Thermodynamic analysis demonstrated that the B–A transition was regulated by the dehydration of the DNA duplex caused by polymer binding.

Graphical abstract: A reversible B–A transition of DNA duplexes induced by synthetic cationic copolymers

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Article information

DOI
https://doi.org/10.1039/C6CC02237E
Article type
Communication
Submitted
14 Mar 2016
Accepted
13 May 2016
First published
16 May 2016
This article is Open Access
Creative Commons BY license

Chem. Commun., 2016,52, 7446-7449

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A reversible B–A transition of DNA duplexes induced by synthetic cationic copolymers

N. Yamaguchi, Y. Zouzumi, N. Shimada, S. Nakano, N. Sugimoto, A. Maruyama and D. Miyoshi, Chem. Commun., 2016, 52, 7446 DOI: 10.1039/C6CC02237E

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