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Issue 57, 2016
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Engineering and manufacturing of pharmaceutical co-crystals: a review of solvent-free manufacturing technologies

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Abstract

Design and synthesis of pharmaceutical cocrystals have received great interest in recent years. Cocrystallization of drug substances offers a tremendous opportunity for the development of new drug products with superior physical and pharmacological properties such as solubility, stability, hydroscopicity, dissolution rates and bioavailability. It is now possible to engineer and develop cocrystals via ‘green chemistry’ and environmentally friendly approaches such as solid-state synthesis in the absence of organic solvents. In addition, significant efforts have been directed towards computational screening, cocrystal manufacturing in a continuous manner and real-time monitoring for quality purposes by using various analytical tools. Pharmaceutical cocrystals are not fully exploited yet and there is a lot of ground to cover before they can be successfully utilized as medical products.

Graphical abstract: Engineering and manufacturing of pharmaceutical co-crystals: a review of solvent-free manufacturing technologies

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Publication details

The article was received on 10 Feb 2016, accepted on 27 May 2016 and first published on 27 May 2016


Article type: Feature Article
DOI: 10.1039/C6CC01289B
Author version available: Download Author version (PDF)
Citation: Chem. Commun., 2016,52, 8772-8786
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    Engineering and manufacturing of pharmaceutical co-crystals: a review of solvent-free manufacturing technologies

    S. A. Ross, D. A. Lamprou and D. Douroumis, Chem. Commun., 2016, 52, 8772
    DOI: 10.1039/C6CC01289B

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