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Issue 27, 2016
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Structural features and molecular aggregations of designed triple-stranded β-sheets in single crystals

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Abstract

Design, synthesis and single-crystal conformations of hybrid triple-stranded β-sheets composed of E-vinylogous residues are reported. Restricting conformational flexibility of β-strands through the insertion of carbon–carbon double bonds at facing positions leads to increased peptide crystallinity, which allowed unambiguous structural characterization of three-stranded β-sheets. This strategy can be further explored for the design of functional β-sheets.

Graphical abstract: Structural features and molecular aggregations of designed triple-stranded β-sheets in single crystals

  • This article is part of the themed collection: Foldamers
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Publication details

The article was received on 06 Jan 2016, accepted on 04 Mar 2016 and first published on 04 Mar 2016


Article type: Communication
DOI: 10.1039/C6CC00127K
Citation: Chem. Commun., 2016,52, 4938-4941
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    Structural features and molecular aggregations of designed triple-stranded β-sheets in single crystals

    A. Bandyopadhyay, R. Misra and H. N. Gopi, Chem. Commun., 2016, 52, 4938
    DOI: 10.1039/C6CC00127K

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