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Issue 19, 2016
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Potent inhibition of cyclic diadenylate monophosphate cyclase by the antiparasitic drug, suramin

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Abstract

C-di-AMP synthases are essential in several bacteria, including human pathogens; hence these enzymes are potential antibiotic targets. However, there is a dearth of small molecule inhibitors of c-di-AMP metabolism enzymes. Screening of 2000 known drugs against DisA has led to the identification of suramin, an antiparasitic drug as potent inhibitor of c-di-AMP synthase.

Graphical abstract: Potent inhibition of cyclic diadenylate monophosphate cyclase by the antiparasitic drug, suramin

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Publication details

The article was received on 21 Dec 2015, accepted on 21 Jan 2016 and first published on 22 Jan 2016


Article type: Communication
DOI: 10.1039/C5CC10446G
Citation: Chem. Commun., 2016,52, 3754-3757
  • Open access: Creative Commons BY license
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    Potent inhibition of cyclic diadenylate monophosphate cyclase by the antiparasitic drug, suramin

    C. Opoku-Temeng and H. O. Sintim, Chem. Commun., 2016, 52, 3754
    DOI: 10.1039/C5CC10446G

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