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Issue 15, 2016
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Rotaxane-mediated suppression and activation of cucurbit[6]uril for molecular detection by 129Xe hyperCEST NMR

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Abstract

We report a method for blocking interactions between 129Xe and cucurbit[6]uril (CB6) until activation by a specific chemical event. We synthesized a CB6–rotaxane that allowed no 129Xe interaction with the CB6 macrocycle component until a cleavage event released the CB6, which then produced a 129Xe@CB6 NMR signal. This contrast-upon-activation 129Xe NMR platform allows for modular synthesis and can be expanded to applications in detection and disease imaging.

Graphical abstract: Rotaxane-mediated suppression and activation of cucurbit[6]uril for molecular detection by 129Xe hyperCEST NMR

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Publication details

The article was received on 18 Dec 2015, accepted on 13 Jan 2016 and first published on 15 Jan 2016


Article type: Communication
DOI: 10.1039/C5CC10410F
Citation: Chem. Commun., 2016,52, 3119-3122
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    Rotaxane-mediated suppression and activation of cucurbit[6]uril for molecular detection by 129Xe hyperCEST NMR

    J. A. Finbloom, C. C. Slack, C. J. Bruns, K. Jeong, D. E. Wemmer, A. Pines and M. B. Francis, Chem. Commun., 2016, 52, 3119
    DOI: 10.1039/C5CC10410F

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