Issue 13, 2016
From the journal:

Chemical Communications

A phosphinate-based near-infrared fluorescence probe for imaging the superoxide radical anion in vitro and in vivo†

Jianjian Zhang,a   Chuwen Li,b   Rui Zhang,a   Fengyuan Zhang,a   Wei Liu,a   Xiaoyan Liu,a   Simon Ming-Yuen Leeb  and  Haixia Zhang*a  

* Corresponding authors

a State Key Laboratory of Applied Organic Chemistry, Key Laboratory of Nonferrous Metals Chemistry and Resources Utilization of Gansu Province and College of Chemistry and Chemical Engineering, Lanzhou University, Lanzhou 730000, China
E-mail: zhanghx@lzu.edu.cn
Fax: +86 931 8912582
Tel: +86 931 8912510

b State Key Laboratory of Quality Research in Chinese Medicine and Institute of Chinese Medical Sciences, University of Macau, Macao, China

Abstract

A novel near-infrared (NIR), turn-on fluorescence probe CyR containing a phosphinate group as a recognizing moiety for the selective detection of O2˙− with a low limit of detection (LOD, 9.9 nM) was developed. CyR has good cell-membrane permeability, intracellular stability, and low cytotoxicity. In addition, we successfully applied the CyR to visualize O2˙− in live zebrafish, mouse and, for the first time, in mouse liver.

Graphical abstract: A phosphinate-based near-infrared fluorescence probe for imaging the superoxide radical anion in vitro and in vivo

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Supplementary files

Article information

DOI
https://doi.org/10.1039/C5CC09976E
Article type
Communication
Submitted
04 Dec 2015
Accepted
05 Jan 2016
First published
05 Jan 2016

Chem. Commun., 2016,52, 2679-2682

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A phosphinate-based near-infrared fluorescence probe for imaging the superoxide radical anion in vitro and in vivo

J. Zhang, C. Li, R. Zhang, F. Zhang, W. Liu, X. Liu, S. M. Lee and H. Zhang, Chem. Commun., 2016, 52, 2679 DOI: 10.1039/C5CC09976E

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