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Issue 5, 2016
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The topochemical synthesis of triazole-linked homobasic DNA

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Abstract

Triazolyl-DNA (TLDNA), a DNA-analog wherein phosphodiester units are replaced by triazole motifs, is of great interest. We have synthesized TLDNA oligomers by adopting the Topochemical Azide–Alkyne Cycloaddition (TAAC) reaction. A nucleoside decorated with the azide and alkyne units crystallized with the proximal placement of the azide and alkyne units of the adjacent molecules and underwent the TAAC reaction to form TLDNA oligomers.

Graphical abstract: The topochemical synthesis of triazole-linked homobasic DNA

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Publication details

The article was received on 24 Oct 2015, accepted on 05 Nov 2015 and first published on 05 Nov 2015


Article type: Communication
DOI: 10.1039/C5CC08834H
Author version available: Download Author version (PDF)
Citation: Chem. Commun., 2016,52, 886-888
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    The topochemical synthesis of triazole-linked homobasic DNA

    A. Pathigoolla and K. M. Sureshan, Chem. Commun., 2016, 52, 886
    DOI: 10.1039/C5CC08834H

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