The one-step synthesis and surface functionalization of dumbbell-like gold–iron oxide nanoparticles: a chitosan-based nanotheranostic system

Nina Kostevsek; Erica Locatelli; Chiara Garrovo; Francesca Arena; Ilaria Monaco; Ivaylo Petrov Nikolov; Saso Sturm; Kristina Zuzek Rozman; Vito Lorusso; Pierangela Giustetto; Paola Bardini; Stefania Biffi; Mauro Comes Franchini

doi:10.1039/C5CC08275G

The one-step synthesis and surface functionalization of dumbbell-like gold–iron oxide nanoparticles: a chitosan-based nanotheranostic system†

Nina Kostevsek,^a Erica Locatelli,^b Chiara Garrovo,^c Francesca Arena,^d Ilaria Monaco,^b Ivaylo Petrov Nikolov,^e Saso Sturm,^a Kristina Zuzek Rozman,^a Vito Lorusso,^f Pierangela Giustetto,^f Paola Bardini,^d Stefania Biffi^c and Mauro Comes Franchini

*^b

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* Corresponding authors

^a Department for Nanostructured Materials K-7, Jozef Stefan Institute, Jamova cesta 39 SI-1000, Ljubljana, Slovenia

^b Department of Industrial Chemistry “Toso Montanari”, University of Bologna, Viale Risorgimento 4, 40136 Bologna, Italy
E-mail: mauro.comesfranchini@unibo.it
Tel: +39-051-2093626

^c Institute for Maternal and Child Health-IRCCS “Burlo Garofolo”, via dell'Istria, 65/1, 34137 Trieste, Italy
Tel: +39-040 3757722

^d Department of Molecular Biotechnology and Health Sciences, Center of Excellence for Preclinical Imaging (CEIP), University of Torino, Via Ribes 5, Colleretto Giacosa, TO, Italy

^e Elettra-Sincrotrone Trieste, Strada Statale 14-km 163.5, 34149 Basovizza, Trieste, Italy

^f Ephoran – Multi-Imaging Solutions – Bioindustry Park Silvano Fumero, Colleretto Giacosa, Torino, Italy

Abstract

The first one-step synthesis of dumbbell-like gold–iron oxide nanoparticles has been reported here. Surface functionalization with a biocompatible chitosan matrix allowed us to obtain a novel targetable diagnostic and therapeutic tool.

Chemical Communications

The one-step synthesis and surface functionalization of dumbbell-like gold–iron oxide nanoparticles: a chitosan-based nanotheranostic system†

Abstract

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The one-step synthesis and surface functionalization of dumbbell-like gold–iron oxide nanoparticles: a chitosan-based nanotheranostic system

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