Two-photon sensitized hollow Gd2O3:Eu3+ nanocomposites for real-time dual-mode imaging and monitoring of anticancer drug release

Tingting Shen; Yu Zhang; Alexander M. Kirillov; Huijuan Cai; Kun Huang; Weisheng Liu; Yu Tang

doi:10.1039/C5CC07609A

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Two-photon sensitized hollow Gd₂O₃:Eu³⁺ nanocomposites for real-time dual-mode imaging and monitoring of anticancer drug release†

Tingting Shen,^a Yu Zhang,^a Alexander M. Kirillov,^b Huijuan Cai,^a Kun Huang,^a Weisheng Liu^a and Yu Tang*^a

Author affiliations

* Corresponding authors

^a State Key Laboratory of Applied Organic Chemistry, Key Laboratory of Nonferrous Metal Chemistry and Resources Utilization of Gansu Province, College of Chemistry and Chemical Engineering, Lanzhou University, Lanzhou 730000, China
E-mail: tangyu@lzu.edu.cn

^b Centro de Quimica Estrutural, Complexo I, Instituto Superior Tecnico, Universidade de Lisboa, Av. Rovisco Pais, Lisbon 1049-001, Portugal

Abstract

New two-photon sensitized multifunctional nanocomposites were designed for dual-mode imaging and real-time drug release monitoring by photoluminescence (PL) and magnetic resonance imaging (MRI). By drug loading based on coordination effect, PL signals of Eu³⁺ and MRI signals of Gd³⁺ can be stabilized and enhanced, respectively, which then display excellent linear decreases on drug release.

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Article information

DOI: https://doi.org/10.1039/C5CC07609A
Article type: Communication
Submitted: 11 Sep 2015
Accepted: 24 Nov 2015
First published: 25 Nov 2015

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Chem. Commun., 2016,52, 1447-1450

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Two-photon sensitized hollow Gd₂O₃:Eu³⁺ nanocomposites for real-time dual-mode imaging and monitoring of anticancer drug release

T. Shen, Y. Zhang, A. M. Kirillov, H. Cai, K. Huang, W. Liu and Y. Tang, Chem. Commun., 2016, 52, 1447 DOI: 10.1039/C5CC07609A

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