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Issue 100, 2015
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TADDOL-based phosphorus(III)-ligands in enantioselective Pd(0)-catalysed C–H functionalisations

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Abstract

Monodentate TADDOL-derived phosphoramidites and phosphonites are versatile chiral ligands for enantioselective Pd(0)-catalysed C–H functionalisations. They enable highly selective cyclisations to access a wide range of chiral carbo- and heterocycles. The high attractiveness of this ligand class consists in their modular structure, allowing for a quick assembly of a library with variable steric properties. Asymmetric C–H functionalisation methods utilising catalytic systems based on Pd(0) complexes and TADDOL-type ligands are presented and aspects of selectivity are discussed.

Graphical abstract: TADDOL-based phosphorus(iii)-ligands in enantioselective Pd(0)-catalysed C–H functionalisations

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Publication details

The article was received on 22 Sep 2015, accepted on 22 Oct 2015 and first published on 26 Oct 2015


Article type: Feature Article
DOI: 10.1039/C5CC07929B
Citation: Chem. Commun., 2015,51, 17647-17657
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    TADDOL-based phosphorus(III)-ligands in enantioselective Pd(0)-catalysed C–H functionalisations

    J. Pedroni and N. Cramer, Chem. Commun., 2015, 51, 17647
    DOI: 10.1039/C5CC07929B

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