Issue 93, 2015
From the journal:

Chemical Communications

Palladium-catalyzed three-component reaction of N-tosyl hydrazones, isonitriles and amines leading to amidines†

Qiang Dai,a   Yan Jiang,a   Jin-Tao Yua  and  Jiang Cheng*a  

* Corresponding authors

a School of Petrochemical Engineering, Jiangsu Key Laboratory of Advanced Catalytic Materials & Technology, Jiangsu Province Key Laboratory of Fine Petrochemical Engineering, Changzhou University, Changzhou, P. R. China
E-mail: jiangcheng@cczu.edu.cn

Abstract

A palladium-catalyzed three-component reaction between N-tosyl hydrazones, aryl isonitriles and amines was developed, leading to amidines in moderate to good yields. This procedure features the rapid construction of amidine frameworks with high diversity and complexity. Ketenimines serve as intermediates, which encounter nucleophilic attack by amines to produce amidines.

Graphical abstract: Palladium-catalyzed three-component reaction of N-tosyl hydrazones, isonitriles and amines leading to amidines

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Article information

DOI
https://doi.org/10.1039/C5CC06771E
Article type
Communication
Submitted
12 Aug 2015
Accepted
15 Sep 2015
First published
21 Sep 2015

Chem. Commun., 2015,51, 16645-16647

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Palladium-catalyzed three-component reaction of N-tosyl hydrazones, isonitriles and amines leading to amidines

Q. Dai, Y. Jiang, J. Yu and J. Cheng, Chem. Commun., 2015, 51, 16645 DOI: 10.1039/C5CC06771E

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