Issue 74, 2015

Reversible DNA i-motif to hairpin switching induced by copper(ii) cations

Abstract

i-Motif DNA structures have previously been utilised for many different nanotechnological applications, but all have used changes in pH to fold the DNA. Herein we describe how copper(II) cations can alter the conformation of i-motif DNA into an alternative hairpin structure which is reversible by chelation with EDTA.

Graphical abstract: Reversible DNA i-motif to hairpin switching induced by copper(ii) cations

Supplementary files

Article information

Article type
Communication
Submitted
22 Jun 2015
Accepted
03 Aug 2015
First published
03 Aug 2015
This article is Open Access
Creative Commons BY license

Chem. Commun., 2015,51, 14099-14102

Author version available

Reversible DNA i-motif to hairpin switching induced by copper(II) cations

H. A. Day, E. P. Wright, C. J. MacDonald, A. J. Gates and Z. A. E. Waller, Chem. Commun., 2015, 51, 14099 DOI: 10.1039/C5CC05111H

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