Issue 62, 2015
From the journal:

Chemical Communications

Fluorophore ATCUN complexes: combining agent and probe for oxidative DNA cleavage†‡

C. Wendea  and  N. Kulak*a  

* Corresponding authors

a Institut für Chemie und Biochemie, Freie Universität Berlin, Fabeckstr. 34/36, 14195 Berlin, Germany
E-mail: nora.kulak@fu-berlin.de
Fax: +49 30 838 454697
Tel: +49 30 838 54697

Abstract

DNA can be oxidatively cleaved by copper complexes of the ATCUN peptide (amino terminal Cu(II)- and Ni(II)-binding motif). In order to investigate the fate of the metal ion throughout this process, we have exploited quenching/dequenching effects of conjugated fluorophores.

Graphical abstract: Fluorophore ATCUN complexes: combining agent and probe for oxidative DNA cleavage

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Article information

DOI
https://doi.org/10.1039/C5CC04508H
Article type
Communication
Submitted
03 Jun 2015
Accepted
22 Jun 2015
First published
22 Jun 2015
This article is Open Access
Creative Commons BY license

Chem. Commun., 2015,51, 12395-12398

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Fluorophore ATCUN complexes: combining agent and probe for oxidative DNA cleavage

C. Wende and N. Kulak, Chem. Commun., 2015, 51, 12395 DOI: 10.1039/C5CC04508H

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