Issue 57, 2015
From the journal:

Chemical Communications

Hydroxylamine-O-sulfonamide is a versatile lead compound for the development of carbonic anhydrase inhibitors†

Anna Di Fiore,*a   Alessandro Vergara,ab   Marco Caterino,b   Vincenzo Alterio,a   Simona M. Monti,a   Joanna Ombouma,c   Pascal Dumy,c   Daniela Vullo,de   Claudiu T. Supuran,de   Jean-Yves Winumc  and  Giuseppina De Simone*a  

* Corresponding authors

a Istituto di Biostrutture e Bioimmagini-CNR, via Mezzocannone 16, 80134 Napoli, Italy
E-mail: anna.difiore@cnr.it, gdesimon@unina.it

b Department of Chemical Sciences, University of Naples Federico II, Napoli, Via Cinthia 80126, Italy

c Institut des Biomolécules Max Mousseron (IBMM) UMR 5247 CNRS, ENSCM, Université de Montpellier, Bâtiment de Recherche Max Mousseron, Ecole Nationale Supérieure de Chimie de Montpellier, 8 rue de l'Ecole Normale, 34296 Montpellier Cedex, France

d Università degli Studi di Firenze, Polo Scientifico, Laboratorio di Chimica Bioinorganica, Rm. 188, Via della Lastruccia 3, 50019 Sesto Fiorentino, Florence, Italy

e NEUROFARBA Department, Sezione di Scienze Farmaceutiche, Via Ugo Schiff 6, 50019 Sesto Fiorentino, Florence, Italy

Abstract

Hydroxylamine-O-sulfonamide, a molecule incorporating two zinc-binding groups (ZBGs), has been investigated as a carbonic anhydrase inhibitor (CAI) by means of kinetic, crystallographic and Raman spectroscopy studies, highlighting interesting results on its mechanism of action. These data can be exploited to design new, effective and selective CAIs.

Graphical abstract: Hydroxylamine-O-sulfonamide is a versatile lead compound for the development of carbonic anhydrase inhibitors

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Article information

DOI
https://doi.org/10.1039/C5CC03711E
Article type
Communication
Submitted
04 May 2015
Accepted
04 Jun 2015
First published
04 Jun 2015

Chem. Commun., 2015,51, 11519-11522

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Hydroxylamine-O-sulfonamide is a versatile lead compound for the development of carbonic anhydrase inhibitors

A. Di Fiore, A. Vergara, M. Caterino, V. Alterio, S. M. Monti, J. Ombouma, P. Dumy, D. Vullo, C. T. Supuran, J. Winum and G. De Simone, Chem. Commun., 2015, 51, 11519 DOI: 10.1039/C5CC03711E

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