Issue 44, 2015
From the journal:

Chemical Communications

An integrin-targeted photoactivatable Pt(iv) complex as a selective anticancer pro-drug: synthesis and photoactivation studies†

Albert Gandioso,a   Evyenia Shaili,b   Anna Massaguer,c   Gerard Artigas,a   Alejandro González-Cantó,a   Julie A. Woods,d   Peter J. Sadlerb  and  Vicente Marchán*a  

* Corresponding authors

a Departament de Química Orgànica and IBUB, Universitat de Barcelona, Barcelona, Spain
E-mail: vmarchan@ub.edu

b Department of Chemistry, University of Warwick, Warwick, Coventry, UK

c Departament de Biologia, Universitat de Girona, Campus Montilivi, Girona, Spain

d Photobiology Unit, Department of Dermatology, Ninewells Hospital, Dundee, UK

Abstract

A new anticancer agent based on the conjugation of a photoactivatable Pt(IV) pro-drug to a cyclic RGD-containing peptide is described. Upon visible light irradiation, phototoxicity was induced preferentially in SK-MEL-28 melanoma cancer cells overexpressing αVβ3 integrin compared to control DU-145 human prostate carcinoma cells.

Graphical abstract: An integrin-targeted photoactivatable Pt(iv) complex as a selective anticancer pro-drug: synthesis and photoactivation studies

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Article information

DOI
https://doi.org/10.1039/C5CC03180J
Article type
Communication
Submitted
16 Apr 2015
Accepted
23 Apr 2015
First published
28 Apr 2015
This article is Open Access
Creative Commons BY license

Chem. Commun., 2015,51, 9169-9172

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An integrin-targeted photoactivatable Pt(IV) complex as a selective anticancer pro-drug: synthesis and photoactivation studies

A. Gandioso, E. Shaili, A. Massaguer, G. Artigas, A. González-Cantó, J. A. Woods, P. J. Sadler and V. Marchán, Chem. Commun., 2015, 51, 9169 DOI: 10.1039/C5CC03180J

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