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Issue 46, 2015
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Targeting VEGF with LNA-stabilized G-rich oligonucleotide for efficient breast cancer inhibition

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Abstract

In this study, we investigated the efficacy of an LNA (locked nucleic acid)-modified DNA aptamer named RNV66 targeting VEGF against various breast cancer cell lines. Our results demonstrate that RNV66 efficiently inhibits breast cancer cell proliferation both in vitro and in vivo. Introduction of LNA nucleotides were crucial for higher efficacy. Furthermore, the binding interaction of RNV66 with VEGF was investigated using molecular dynamic simulations leading to the first computational model of the LNA aptamer–VEGF complex blocking its interaction with VEGF-receptor.

Graphical abstract: Targeting VEGF with LNA-stabilized G-rich oligonucleotide for efficient breast cancer inhibition

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Publication details

The article was received on 02 Apr 2015, accepted on 07 May 2015 and first published on 07 May 2015


Article type: Communication
DOI: 10.1039/C5CC02756J
Author version available: Download Author version (PDF)
Citation: Chem. Commun., 2015,51, 9499-9502
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    Targeting VEGF with LNA-stabilized G-rich oligonucleotide for efficient breast cancer inhibition

    S. L. Edwards, V. Poongavanam, J. R. Kanwar, K. Roy, K. M. Hillman, N. Prasad, R. Leth-Larsen, M. Petersen, M. Marušič, J. Plavec, J. Wengel and R. N. Veedu, Chem. Commun., 2015, 51, 9499
    DOI: 10.1039/C5CC02756J

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