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Issue 25, 2015
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Promiscuous hydroxylases for the functionalization of polycyclic tetramate macrolactams – conversion of ikarugamycin to butremycin

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Abstract

Polycyclic tetramate macrolactams (PTMs) are a structurally, biomedically and biosynthetically intriguing class of bacterial metabolites. By combining parts of the machineries of different PTM biosynthetic pathways, we demonstrate for the first time the substrate promiscuity of a class of PTM tailoring enzymes, thereby facilitating the (bio)synthesis of butremycin.

Graphical abstract: Promiscuous hydroxylases for the functionalization of polycyclic tetramate macrolactams – conversion of ikarugamycin to butremycin

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Publication details

The article was received on 29 Jan 2015, accepted on 20 Feb 2015 and first published on 20 Feb 2015


Article type: Communication
DOI: 10.1039/C5CC00843C
Citation: Chem. Commun., 2015,51, 5334-5336
  • Open access: Creative Commons BY-NC license
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    Promiscuous hydroxylases for the functionalization of polycyclic tetramate macrolactams – conversion of ikarugamycin to butremycin

    C. Greunke, J. Antosch and T. A. M. Gulder, Chem. Commun., 2015, 51, 5334
    DOI: 10.1039/C5CC00843C

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