Issue 19, 2015
From the journal:

Chemical Communications

Palladium-catalyzed oxidative carbamoylation of isoquinoline N-oxides with formylamides by means of dual C–H oxidative coupling†

Bo Yao,a   Chen-Liang Deng,a   Yan Liu,a   Ri-Yuan Tang,a   Xing-Guo Zhang*a  and  Jin-Heng Li*b  

* Corresponding authors

a College of Chemistry and Materials Engineering, Wenzhou University, Wenzhou 325035, China
E-mail: zxg@wzu.edu.cn

b State Key Laboratory of Chemo/Biosensing and Chemometrics, College of Chemistry and Chemical Engineering, Hunan University, Changsha 410082, China
E-mail: jhli@hnu.edu.cn

Abstract

A new palladium-catalyzed oxidative carbamoylation reaction of isoquinoline N-oxides with formylamides for the synthesis of isoquinoline-1-carboxamides is established. The method represents the first example of the carbamoylation of isoquinoline N-oxides with formylamides to furnish arylamides using the dual C–H oxidation strategy.

Graphical abstract: Palladium-catalyzed oxidative carbamoylation of isoquinoline N-oxides with formylamides by means of dual C–H oxidative coupling

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Article information

DOI
https://doi.org/10.1039/C4CC10140E
Article type
Communication
Submitted
19 Dec 2014
Accepted
27 Jan 2015
First published
27 Jan 2015

Chem. Commun., 2015,51, 4097-4100

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Palladium-catalyzed oxidative carbamoylation of isoquinoline N-oxides with formylamides by means of dual C–H oxidative coupling

B. Yao, C. Deng, Y. Liu, R. Tang, X. Zhang and J. Li, Chem. Commun., 2015, 51, 4097 DOI: 10.1039/C4CC10140E

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