Issue 12, 2015
From the journal:

Chemical Communications

Interaction of Aβ peptide with tubulin causes an inhibition of tubulin polymerization and the apoptotic death of cancer cells†‡

Abhijit Saha,a   Saswat Mohapatra,a   Prashant Kurkute,a   Batakrishna Jana,a   Prasenjit Mondal,a   Debmalya Bhunia,a   Subhajit Ghosha  and  Surajit Ghosh*a  

* Corresponding authors

a Chemistry Division, CSIR-Indian Institute of Chemical Biology, 4 Raja S. C. Mullick Road, Jadavpur, Kolkata-700032, West Bengal, India
E-mail: sghosh@iicb.res.in
Fax: +91-33-2473-5197/0284
Tel: +91-33-2499-5872

Abstract

We report in this work that the Aβ peptide directly interacts with tubulin close to the vinblastine and GTP/GDP binding site, inhibits the tubulin polymerization rate, induces tubulin aggregation, causes cell shrinking, enhances Mad2, BubR1, p53, and p21 activation in MCF7 cells and induces the apoptotic death of A549, HeLa and MCF7 cells.

Graphical abstract: Interaction of Aβ peptide with tubulin causes an inhibition of tubulin polymerization and the apoptotic death of cancer cells

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Article information

DOI
https://doi.org/10.1039/C4CC09390A
Article type
Communication
Submitted
24 Nov 2014
Accepted
10 Dec 2014
First published
10 Dec 2014

Chem. Commun., 2015,51, 2249-2252

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Interaction of Aβ peptide with tubulin causes an inhibition of tubulin polymerization and the apoptotic death of cancer cells

A. Saha, S. Mohapatra, P. Kurkute, B. Jana, P. Mondal, D. Bhunia, S. Ghosh and S. Ghosh, Chem. Commun., 2015, 51, 2249 DOI: 10.1039/C4CC09390A

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