Issue 2, 2015
From the journal:

Chemical Communications

Long-term thiol monitoring in living cells using bioorthogonal chemistry†

Lei Rong,a   Chi Zhang,a   Qi Lei,a   Hua-Ling Sun,b   Si-Yong Qin,a   Jun Fenga  and  Xian-Zheng Zhang*ac  

* Corresponding authors

a Key Laboratory of Biomedical Polymers of Ministry of Education & Department of Chemistry, Wuhan University, Wuhan 430072, P. R. China
E-mail: xz-zhang@whu.edu.cn

b The State Key Laboratory Breeding Base of Basic Science of Stomatology (Hubei-MOST) & Key Laboratory of Oral Biomedicine Ministry of Education, School & Hospital of Stomatology, Wuhan University, Wuhan 430072, P. R. China

c Collaborative Innovation Center of Chemical Science and Engineering (Tianjin), Tianjin 300072, P. R. China

Abstract

Intracellular thiols play vital roles in living systems, and their in situ monitoring is of great importance. Here, we report on a bioorthogonal chemistry based fluorescent probe, which is capable of monitoring intracellular thiols in living cells for up to 36 hours with an obvious blue-to-green fluorescence change.

Graphical abstract: Long-term thiol monitoring in living cells using bioorthogonal chemistry

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Article information

DOI
https://doi.org/10.1039/C4CC08396B
Article type
Communication
Submitted
24 Oct 2014
Accepted
07 Nov 2014
First published
07 Nov 2014

Chem. Commun., 2015,51, 388-390

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Long-term thiol monitoring in living cells using bioorthogonal chemistry

L. Rong, C. Zhang, Q. Lei, H. Sun, S. Qin, J. Feng and X. Zhang, Chem. Commun., 2015, 51, 388 DOI: 10.1039/C4CC08396B

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