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Issue 6, 2015
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Capture and Release (CaR): a simplified procedure for one-tube isolation and concentration of single-stranded DNA during SELEX

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Abstract

Short biotinylated oligodeoxynucleotides immobilized on streptavidin-coated magnetic beads allow for convenient and rapid purification of single-stranded oligodeoxynucleotides from crude asymmetric PCR mixtures, facilitating the selection of DNA aptamers.

Graphical abstract: Capture and Release (CaR): a simplified procedure for one-tube isolation and concentration of single-stranded DNA during SELEX

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Publication details

The article was received on 17 Oct 2014, accepted on 27 Nov 2014 and first published on 27 Nov 2014


Article type: Communication
DOI: 10.1039/C4CC08233H
Citation: Chem. Commun., 2015,51, 1135-1138
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    Capture and Release (CaR): a simplified procedure for one-tube isolation and concentration of single-stranded DNA during SELEX

    N. S. Hamedani, F. Blümke, F. Tolle, F. Rohrbach, H. Rühl, J. Oldenburg, G. Mayer, B. Pötzsch and J. Müller, Chem. Commun., 2015, 51, 1135
    DOI: 10.1039/C4CC08233H

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