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Issue 2, 2015
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A novel leucine zipper motif-based hybrid peptide delivers a functional peptide cargo inside cells

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Abstract

A hybrid comprising an autophagy-inducing peptide (AIP) and a cell-penetrating peptide (CPP) connected via heterodimeric leucine zippers was generated and delivered into cells. The hybrid successfully induced autophagy without significant cell death, while the same AIP directly connected to a CPP caused both autophagy and significant cell death.

Graphical abstract: A novel leucine zipper motif-based hybrid peptide delivers a functional peptide cargo inside cells

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Publication details

The article was received on 22 Sep 2014, accepted on 06 Nov 2014 and first published on 18 Nov 2014


Article type: Communication
DOI: 10.1039/C4CC07459A
Author version available: Download Author version (PDF)
Citation: Chem. Commun., 2015,51, 413-416
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    A novel leucine zipper motif-based hybrid peptide delivers a functional peptide cargo inside cells

    Y. Hakata, S. Tsuchiya, H. Michiue, T. Ohtsuki, H. Matsui, M. Miyazawa and M. Kitamatsu, Chem. Commun., 2015, 51, 413
    DOI: 10.1039/C4CC07459A

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