Rhodium(iii)-catalysed aerobic synthesis of highly functionalized indoles from N-arylurea under mild conditions through C–H activation†
Abstract
A Rh(III) catalysed amino arylation of alkynes using copper as the terminal oxidant for regeneration of the catalytically active species under aerobic conditions is described. This novel C–H activation reaction was applied to the synthesis of a wide range of substituted indoles from N-arylureas.