Issue 79, 2014

Rapid engineering of versatile molecular logic gates using heterologous genetic transcriptional modules

Abstract

We designed and constructed versatile modular genetic logic gates in bacterial cells. These function as digital logic 1-input Buffer gate, 2-input and 3-input AND gates with one inverted input and integrate multiple chemical input signals in customised logic manners. Such rapidly engineered devices serve to achieve increased sensing signal selectivity.

Graphical abstract: Rapid engineering of versatile molecular logic gates using heterologous genetic transcriptional modules

Supplementary files

Article information

Article type
Communication
Submitted
08 Jul 2014
Accepted
21 Jul 2014
First published
21 Jul 2014
This article is Open Access
Creative Commons BY-NC license

Chem. Commun., 2014,50, 11642-11644

Author version available

Rapid engineering of versatile molecular logic gates using heterologous genetic transcriptional modules

B. Wang and M. Buck, Chem. Commun., 2014, 50, 11642 DOI: 10.1039/C4CC05264A

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