Issue 74, 2014

An umpolung approach toward N-aryl nitrone construction: a phosphine-mediated addition of 1,2-dicarbonyls to nitroso electrophiles

Abstract

An umpolung approach toward nitrone construction utilizing a phosphine-mediated addition of 1,2-dicarbonyls to nitroso compounds is reported. The reaction exhibits a high degree of chemoselectivity and provides direct access to isoxazolidines, imines, and trisubstituted alkenes.

Graphical abstract: An umpolung approach toward N-aryl nitrone construction: a phosphine-mediated addition of 1,2-dicarbonyls to nitroso electrophiles

Supplementary files

Article information

Article type
Communication
Submitted
03 Jul 2014
Accepted
24 Jul 2014
First published
24 Jul 2014

Chem. Commun., 2014,50, 10853-10856

Author version available

An umpolung approach toward N-aryl nitrone construction: a phosphine-mediated addition of 1,2-dicarbonyls to nitroso electrophiles

A. P. Chavannavar, A. G. Oliver and B. L. Ashfeld, Chem. Commun., 2014, 50, 10853 DOI: 10.1039/C4CC05044D

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