Issue 67, 2014
From the journal:

Chemical Communications

A modular designed copolymer with anti-thrombotic activity and imaging capability†

Nan Xie,‡a   Ke Feng,‡b   Bin Chen,b   Ming Zhao,*ac   Li-Ping Zhang,b   Chen-Ho Tung,b   Li-Zhu Wu*b  and  Shiqi Peng*a  

* Corresponding authors

a School of Chemical Biology and Pharmaceutical Sciences, Capital Medical University, Beijing 100069, P. R. China
E-mail: mingzhao@bjmu.edu.cn, sqpeng@bjmu.edu.cn

b Key Laboratory of Photochemical Conversion and Optoelectronic Materials, Technical Institute of Physics and Chemistry, The Chinese Academy of Sciences, Beijing 100190, P. R. China
E-mail: lzwu@mail.ipc.ac.cn

c Department of Biomedical Science and Environmental Biology, Kaohsiung Medical University, Kaohsiung, Taiwan

Abstract

Through a modular ROMP (ring-opening metathesis polymerization) strategy, a random copolymer with anti-thrombotic activity and imaging capability has been constructed from RGD, rhodamine B and PEG modified norbornene monomers. As we expected, these tri-component polynorbornenes exhibit significant enhancement in anti-thrombotic efficacy and bioavailability in vivo.

Graphical abstract: A modular designed copolymer with anti-thrombotic activity and imaging capability

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Article information

DOI
https://doi.org/10.1039/C4CC04649H
Article type
Communication
Submitted
19 Jun 2014
Accepted
04 Jul 2014
First published
07 Jul 2014

Chem. Commun., 2014,50, 9539-9542

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A modular designed copolymer with anti-thrombotic activity and imaging capability

N. Xie, K. Feng, B. Chen, M. Zhao, L. Zhang, C. Tung, L. Wu and S. Peng, Chem. Commun., 2014, 50, 9539 DOI: 10.1039/C4CC04649H

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