Issue 86, 2014
From the journal:

Chemical Communications

Synthesis of rhodamine-labelled dieckol: its unique intracellular localization and potent anti-inflammatory activity†

Jong Hwan Kwak,‡a   Yanxia He,‡b   Byungkwon Yoon,b   Seyoung Koo,b   Zhigang Yang,b   Eun Ju Kang,c   Bong Ho Lee,d   Seung-Yun Han,e   Yung Choon Yoo,*c   Kyung Bok Lee*f  and  Jong Seung Kim*b  

* Corresponding authors

a School of Pharmacy, Sungkyunkwan University, Suwon 440-746, Korea

b Department of Chemistry, Korea University, Seoul 136-701, Korea
E-mail: jongskim@korea.ac.kr

c Department of Microbiology, College of Medicine, Konyang University, Daejeon 302-718, Korea
E-mail: yc_yoo@konyang.ac.kr

d Department of Chemical and Biological Engineering, College of Engineering, Hanbat National University, Daejeon 305-717, Korea

e Department of Anatomy, College of Medicine, Konyang University, Daejeon 302-718, Korea

f Department of Biochemistry, College of Medicine, Konyang University, Daejeon 302-718, Korea
E-mail: kyunglee@konyang.ac.kr

Abstract

Rhodamine-labelled dieckol (1) synthesized through a click reaction was found to be localized in the endoplasmic reticulum (ER) of RAW 264.7 cells. Anti-inflammatory activity of compound 1 was considerably greater than that of dieckol itself.

Graphical abstract: Synthesis of rhodamine-labelled dieckol: its unique intracellular localization and potent anti-inflammatory activity

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Article information

DOI
https://doi.org/10.1039/C4CC04270K
Article type
Communication
Submitted
04 Jun 2014
Accepted
09 Jul 2014
First published
10 Jul 2014

Chem. Commun., 2014,50, 13045-13048

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Synthesis of rhodamine-labelled dieckol: its unique intracellular localization and potent anti-inflammatory activity

J. H. Kwak, Y. He, B. Yoon, S. Koo, Z. Yang, E. J. Kang, B. H. Lee, S. Han, Y. C. Yoo, K. B. Lee and J. S. Kim, Chem. Commun., 2014, 50, 13045 DOI: 10.1039/C4CC04270K

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