Palladium-catalyzed oxidative CH/CH cross-coupling of pyridine N-oxides with five-membered heterocycles

Abstract

Using Ag₂CO₃ as an additive, we developed the Pd-catalyzed intermolecular C–H/C–H cross-coupling of pyridine N-oxides with five-membered heterocycles such as 1-benzyl-1,2,3-triazoles, thiophens and furans. This protocol provides an efficient and regioselective approach for the synthesis of unsymmetrical biheteroaryl molecules.