Issue 83, 2014

Sulfonyl azide-mediated norbornene aziridination for orthogonal peptide and protein labeling

Abstract

We describe a new bioconjugation reaction based on the aziridination of norbornenes using electron-deficient sulfonyl azides. The reaction enables to attach various useful tags to peptides and proteins under mild conditions.

Graphical abstract: Sulfonyl azide-mediated norbornene aziridination for orthogonal peptide and protein labeling

Supplementary files

Article information

Article type
Communication
Submitted
29 May 2014
Accepted
27 Aug 2014
First published
29 Aug 2014

Chem. Commun., 2014,50, 12568-12571

Author version available

Sulfonyl azide-mediated norbornene aziridination for orthogonal peptide and protein labeling

M. J. Gattner, M. Ehrlich and M. Vrabel, Chem. Commun., 2014, 50, 12568 DOI: 10.1039/C4CC04117H

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