An H2O2-responsive nanocarrier for dual-release of platinum anticancer drugs and O2: controlled release and enhanced cytotoxicity against cisplatin resistant cancer cells

Huachao Chen; Weijiang He; Zijian Guo

doi:10.1039/C4CC03385J

You do not have JavaScript enabled. Please enable JavaScript to access the full features of the site or access our non-JavaScript page.

An H₂O₂-responsive nanocarrier for dual-release of platinum anticancer drugs and O₂: controlled release and enhanced cytotoxicity against cisplatin resistant cancer cells†

Huachao Chen,^a Weijiang He*^a and Zijian Guo*^a

Author affiliations

* Corresponding authors

^a State Key Laboratory of Coordination Chemistry, Coordination Chemistry Institute, School of Chemistry and Chemical Engineering, Nanjing University, Nanjing 210093, P. R. China
E-mail: heweij69@nju.edu.cn, zguo@nju.edu.cn
Fax: +86 25 83314502
Tel: +86 25 83597066

Abstract

Synergistic release of platinum anticancer drugs and O₂ can be achieved in an H₂O₂-responsive nanocarrier incorporated with catalase. Such a system combines the advantages of chemotherapy and oxygen therapy and demonstrated improved therapeutic efficacy against cisplatin resistant cell lines which often appear to be in hypoxia.

Download options Please wait...

Supplementary files

Article information

DOI: https://doi.org/10.1039/C4CC03385J
Article type: Communication
Submitted: 06 May 2014
Accepted: 25 Jun 2014
First published: 25 Jun 2014

Download Citation

Chem. Commun., 2014,50, 9714-9717

Author version available

Download author version (PDF)

Permissions

Request permissions

An H₂O₂-responsive nanocarrier for dual-release of platinum anticancer drugs and O₂: controlled release and enhanced cytotoxicity against cisplatin resistant cancer cells

H. Chen, W. He and Z. Guo, Chem. Commun., 2014, 50, 9714 DOI: 10.1039/C4CC03385J

To request permission to reproduce material from this article, please go to the Copyright Clearance Center request page.

If you are an author contributing to an RSC publication, you do not need to request permission provided correct acknowledgement is given.

If you are the author of this article, you do not need to request permission to reproduce figures and diagrams provided correct acknowledgement is given. If you want to reproduce the whole article in a third-party publication (excluding your thesis/dissertation for which permission is not required) please go to the Copyright Clearance Center request page.

Social activity

Fetching data from CrossRef.
This may take some time to load.

Chemical Communications