Issue 75, 2014
From the journal:

Chemical Communications

A DNA-templated synthesis of encoded small molecules by DNA self-assembly†

Cheng Cao,a   Peng Zhao,a   Ze Li,a   Zitian Chen,c   Yanyi Huang,c   Yu Bai*a  and  Xiaoyu Li*ab  

* Corresponding authors

a Key Laboratory of Bioorganic Chemistry and Molecular Engineering of the Ministry of Education, Beijing National Laboratory of Molecular Sciences (BNLMS), College of Chemistry and Molecular Engineering, Peking University, Beijing, China 100871
E-mail: xiaoyuli@pku.edu.cn, yu.bai@pku.edu.cn

b Key Laboratory of Chemical Genomics, School of Chemical Biology and Biotechnology, Peking University Shenzhen Graduate School, Shenzhen, China 518055

c Biodynamic Optical Imaging Center (BIOPIC) and College of Engineering, Peking University, Beijing, China 100871

Abstract

We report a novel method for the synthesis of DNA-encoded libraries without the need for discrete DNA template. Reactant DNAs self-assemble to enable chemical reactions and photo-cleavage transfers the product to the DNA terminus, making it suitable for the subsequent affinity-based selection and hit deconvolution.

Graphical abstract: A DNA-templated synthesis of encoded small molecules by DNA self-assembly

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Article information

DOI
https://doi.org/10.1039/C4CC03380A
Article type
Communication
Submitted
06 May 2014
Accepted
28 Jul 2014
First published
28 Jul 2014

Chem. Commun., 2014,50, 10997-10999

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A DNA-templated synthesis of encoded small molecules by DNA self-assembly

C. Cao, P. Zhao, Z. Li, Z. Chen, Y. Huang, Y. Bai and X. Li, Chem. Commun., 2014, 50, 10997 DOI: 10.1039/C4CC03380A

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