Issue 55, 2014

Palladium catalyzed, heteroatom-guided C–H functionalization in the synthesis of substituted isoquinolines and dihydroisoquinolines

Abstract

A new approach for the functionalization of C-4 of isoquinolines is reported. The method utilizes palladium catalyzed, hetero-atom guided (or electrophilic metalation) direct arylation via regioselective C–H functionalization of dihydroisoquinolines.

Graphical abstract: Palladium catalyzed, heteroatom-guided C–H functionalization in the synthesis of substituted isoquinolines and dihydroisoquinolines

Supplementary files

Article information

Article type
Communication
Submitted
28 Apr 2014
Accepted
19 May 2014
First published
29 May 2014

Chem. Commun., 2014,50, 7322-7325

Palladium catalyzed, heteroatom-guided C–H functionalization in the synthesis of substituted isoquinolines and dihydroisoquinolines

V. K. Tiwari, G. G. Pawar, H. S. Jena and M. Kapur, Chem. Commun., 2014, 50, 7322 DOI: 10.1039/C4CC03165B

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