Issue 56, 2014
From the journal:

Chemical Communications

Microwave-assisted preparation of nucleoside-phosphoramidites†

G. Meher,a   T. Efthymiou,a   M. Stoopa  and  R. Krishnamurthy*a  

* Corresponding authors

a Department of Chemistry, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, CA 92037, USA
E-mail: rkrishna@scripps.edu

Abstract

Microwave-assisted phosphitylation of sterically hindered nucleosides is demonstrated to be an efficient method for the preparation of corresponding phosphoramidites (otherwise onerous under standard conditions) and is shown to be general in its applicability.

Graphical abstract: Microwave-assisted preparation of nucleoside-phosphoramidites

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Article information

DOI
https://doi.org/10.1039/C4CC03092C
Article type
Communication
Submitted
25 Apr 2014
Accepted
16 May 2014
First published
16 May 2014

Chem. Commun., 2014,50, 7463-7465

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Microwave-assisted preparation of nucleoside-phosphoramidites

G. Meher, T. Efthymiou, M. Stoop and R. Krishnamurthy, Chem. Commun., 2014, 50, 7463 DOI: 10.1039/C4CC03092C

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