Issue 43, 2014

Synthesis and in vitro assessment of a bifunctional closomer probe for fluorine (19F) magnetic resonance and optical bimodal cellular imaging

Abstract

The design, synthesis and in vitro assessment of a bifunctional imaging probe for dual fluorine (19F) magnetic resonance spectroscopy (19F-MRS) and fluorescence detection is reported. Eleven copies of 3,5-bis(trifluoromethyl)phenyl and a single copy of a sulforhodamine-B were covalently attached to a closo-B122−-core via suitable linkers. The 19F-MRS and fluorescence imaging shows that, this novel bimodal imaging probe was readily taken up by the cells in vitro after co-incubation.

Graphical abstract: Synthesis and in vitro assessment of a bifunctional closomer probe for fluorine (19F) magnetic resonance and optical bimodal cellular imaging

Supplementary files

Article information

Article type
Communication
Submitted
21 Mar 2014
Accepted
15 Apr 2014
First published
15 Apr 2014

Chem. Commun., 2014,50, 5793-5795

Author version available

Synthesis and in vitro assessment of a bifunctional closomer probe for fluorine (19F) magnetic resonance and optical bimodal cellular imaging

L. N. Goswami, A. A. Khan, S. S. Jalisatgi and M. F. Hawthorne, Chem. Commun., 2014, 50, 5793 DOI: 10.1039/C4CC02126F

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