Issue 44, 2014

Copper-catalyzed olefinic C–H difluoroacetylation of enamides

Abstract

Copper-catalyzed olefinic difluoroacetylation of enamides via direct C–H bond functionalization using BrCF2CO2Et is reported for the first time. It constitutes an efficient radical-free method for the regioselective synthesis of β-difluoroester substituted enamides which exhibits broad substrate scope, and thus demonstrates its potent application in a late stage fluorination strategy.

Graphical abstract: Copper-catalyzed olefinic C–H difluoroacetylation of enamides

Supplementary files

Article information

Article type
Communication
Submitted
17 Mar 2014
Accepted
10 Apr 2014
First published
11 Apr 2014

Chem. Commun., 2014,50, 5887-5890

Author version available

Copper-catalyzed olefinic C–H difluoroacetylation of enamides

G. Caillot, J. Dufour, M. Belhomme, T. Poisson, L. Grimaud, X. Pannecoucke and I. Gillaizeau, Chem. Commun., 2014, 50, 5887 DOI: 10.1039/C4CC01994F

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