Issue 43, 2014
From the journal:

Chemical Communications

Total synthesis of (+)-kopsihainanine A†

Masaya Mizutani,a   Shigeo Yasudaa  and  Chisato Mukai*a  

* Corresponding authors

a Division of Pharmaceutical Sciences, Graduate School of Medical Sciences, Kanazawa University, Kakuma-machi, Kanazawa 920-1192, Japan
E-mail: mukai@p.kanazawa-u.ac.jp
Fax: +81-76-234-4410
Tel: +81-76-234-4411

Abstract

Total synthesis of (+)-kopsihainanine A was accomplished on the basis of (i) Stoltz's enantioselective decarboxylative asymmetric allylation and (ii) the proposed biogenetic pathway from the related alkaloid, kopsihainanine B. In addition, HPLC analysis of the synthetic (+)-kopsihainanine A confirmed its ee to be 99% with [α]30D = 25.35.

Graphical abstract: Total synthesis of (+)-kopsihainanine A

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Article information

DOI
https://doi.org/10.1039/C4CC01843E
Article type
Communication
Submitted
12 Mar 2014
Accepted
14 Apr 2014
First published
14 Apr 2014

Chem. Commun., 2014,50, 5782-5785

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Total synthesis of (+)-kopsihainanine A

M. Mizutani, S. Yasuda and C. Mukai, Chem. Commun., 2014, 50, 5782 DOI: 10.1039/C4CC01843E

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