Issue 41, 2014

Asymmetric synthesis of heteroaryl atropisomers via a gold-catalyzed cycloisomerization–amination cascade reaction

Abstract

The chiral gold(I) complex enables enantioselective cycloisomerization–amination of 2-(alkynyl)phenyl boronic acids and diazenes in high yields. A wide scope of substrates bearing various functional groups was tolerated to generate structurally different hydrazide derivatives as a new type of atropisomer.

Graphical abstract: Asymmetric synthesis of heteroaryl atropisomers via a gold-catalyzed cycloisomerization–amination cascade reaction

Supplementary files

Article information

Article type
Communication
Submitted
23 Feb 2014
Accepted
19 Mar 2014
First published
20 Mar 2014

Chem. Commun., 2014,50, 5451-5454

Author version available

Asymmetric synthesis of heteroaryl atropisomers via a gold-catalyzed cycloisomerization–amination cascade reaction

R. Guo, K. Li, B. Liu, H. Zhu, Y. Fan and L. Gong, Chem. Commun., 2014, 50, 5451 DOI: 10.1039/C4CC01397B

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