Issue 74, 2014

AgNO2-mediated direct nitration of the quinoxaline tertiary benzylic C–H bond and direct conversion of 2-methyl quinoxalines into related nitriles

Abstract

A unique method for AgNO2-mediated direct nitration of the quinoxaline tertiary C–H bond and direct conversion of 2-methyl quinoxalines into 2-quinoxaline nitriles under oxidative conditions has been developed. This protocol provides an efficient way to access quinoxaline containing nitroalkanes and nitriles depending on different substrate selection.

Graphical abstract: AgNO2-mediated direct nitration of the quinoxaline tertiary benzylic C–H bond and direct conversion of 2-methyl quinoxalines into related nitriles

Supplementary files

Article information

Article type
Communication
Submitted
20 Feb 2014
Accepted
21 Jul 2014
First published
25 Jul 2014

Chem. Commun., 2014,50, 10857-10860

Author version available

AgNO2-mediated direct nitration of the quinoxaline tertiary benzylic C–H bond and direct conversion of 2-methyl quinoxalines into related nitriles

D. Wu, J. Zhang, J. Cui, W. Zhang and Y. Liu, Chem. Commun., 2014, 50, 10857 DOI: 10.1039/C4CC01327A

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