Issue 33, 2014

Synthesis of 3-trifluoromethylpyrazoles via trifluoromethylation/cyclization of α,β-alkynic hydrazones using a hypervalent iodine reagent

Abstract

A mild and efficient method for the synthesis of 3-trifluoromethylpyrazoles has been established via trifluoromethylation/cyclization of α,β-alkynic hydrazones using a hypervalent iodine reagent under transition-metal-free conditions.

Graphical abstract: Synthesis of 3-trifluoromethylpyrazoles via trifluoromethylation/cyclization of α,β-alkynic hydrazones using a hypervalent iodine reagent

Supplementary files

Article information

Article type
Communication
Submitted
18 Feb 2014
Accepted
04 Mar 2014
First published
05 Mar 2014

Chem. Commun., 2014,50, 4361-4363

Author version available

Synthesis of 3-trifluoromethylpyrazoles via trifluoromethylation/cyclization of α,β-alkynic hydrazones using a hypervalent iodine reagent

G. Ji, X. Wang, S. Zhang, Y. Xu, Y. Ye, M. Li, Y. Zhang and J. Wang, Chem. Commun., 2014, 50, 4361 DOI: 10.1039/C4CC01280A

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