Issue 49, 2014
From the journal:

Chemical Communications

TACN-based oligomers with aromatic backbones for efficient nucleic acid delivery†

Wen-Jing Yi,a   Xing-Chi Yu,a   Bing Wang,a   Ji Zhang,*a   Qing-Ying Yu,a   Xue-Dong Zhou*b  and  Xiao-Qi Yu*a  

* Corresponding authors

a Key Laboratory of Green Chemistry and Technology (Ministry of Education), College of Chemistry, Sichuan University, Chengdu 610064, PR China
E-mail: xqyu@scu.edu.cn, ji_zhang@163.com
Fax: +86-28-85415886

b State Key Laboratory of Oral Diseases, Sichuan University, Chengdu 610041, PR China
E-mail: zhouxd@scu.edu.cn

Abstract

Cationic oligomers with a rigid aromatic backbone were first applied as non-viral gene delivery vectors. These materials showed better DNA condensation ability than their flexible analogues. In vitro transfection experiments revealed that the materials with more rigid backbone exhibited considerably higher TE and lower cytotoxicity than 25 kDa PEI.

Graphical abstract: TACN-based oligomers with aromatic backbones for efficient nucleic acid delivery

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Article information

DOI
https://doi.org/10.1039/C4CC01210K
Article type
Communication
Submitted
16 Feb 2014
Accepted
27 Mar 2014
First published
27 Mar 2014

Chem. Commun., 2014,50, 6454-6457

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TACN-based oligomers with aromatic backbones for efficient nucleic acid delivery

W. Yi, X. Yu, B. Wang, J. Zhang, Q. Yu, X. Zhou and X. Yu, Chem. Commun., 2014, 50, 6454 DOI: 10.1039/C4CC01210K

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