Issue 39, 2014
From the journal:

Chemical Communications

Synthesis of 1H-indazoles from N-tosylhydrazones and nitroaromatic compounds†

Zhenxing Liu,a   Long Wang,a   Haocheng Tan,a   Shiyi Zhou,a   Tianren Fu,a   Ying Xia,a   Yan Zhanga  and  Jianbo Wang*a  

* Corresponding authors

a Beijing National Laboratory of Molecular Sciences (BNLMS) and Key Laboratory of Bioorganic Chemistry and Molecular Engineering of Ministry of Education, College of Chemistry, Peking University, Beijing 100871, China
E-mail: wangjb@pku.edu.cn
Fax: +86 10 6275-1708

Abstract

A new method for the synthesis of 1H-indazoles from readily available N-tosylhydrazones and nitroaromatic compounds has been developed. This transformation occurs under transition-metal-free conditions and shows a wide substrate scope. The method has been successfully applied to the formal synthesis of a bioactive compound, WAY-169916.

Graphical abstract: Synthesis of 1H-indazoles from N-tosylhydrazones and nitroaromatic compounds

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Article information

DOI
https://doi.org/10.1039/C4CC00962B
Article type
Communication
Submitted
05 Feb 2014
Accepted
26 Mar 2014
First published
26 Mar 2014

Chem. Commun., 2014,50, 5061-5063

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Synthesis of 1H-indazoles from N-tosylhydrazones and nitroaromatic compounds

Z. Liu, L. Wang, H. Tan, S. Zhou, T. Fu, Y. Xia, Y. Zhang and J. Wang, Chem. Commun., 2014, 50, 5061 DOI: 10.1039/C4CC00962B

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